Published 1994 by Agricultural Experiment Station, University of Illinois in Urbana, Ill .
Written in EnglishRead online
|Other titles||Willard J. Visek : from ammonia to cancer and gene expression, Proceedings from a symposium honoring Willard J. Visek|
|Statement||sponsored by Division of Nutritional Sciences ... [et al.]|
|Series||Special publication -- 86, Special publication (University of Illinois at Urbana-Champaign. College of Agriculture) -- no. 86|
|Contributions||University of Illinois at Urbana-Champaign. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign. Agricultural Experiment Station|
|The Physical Object|
|Pagination||v, 64 p. :|
|Number of Pages||64|
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Get this from a library. From ammonia to cancer and gene expression: proceedings from a symposium honoring Willard J. Visek. [University of Illinois at Urbana-Champaign. Division of Nutritional Sciences.; University of Illinois at Urbana-Champaign. Agricultural Experiment Station.;].
g, Kaplan–Meier survival curves of patients with colon cancer based on CPS1 (left), OTC (middle) or ARG1 (right) expression. Data were generated from Gene Expression Cited by: Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer.
In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying. Cancer: Disease of Altered Gene Expression. Cancer can be described as a disease of altered gene expression.
There are many proteins that are turned on or off (gene activation or gene silencing) that dramatically alter the overall activity of the cell. A gene that is not normally expressed in that cell can be switched on and expressed at high Author: Lisa Bartee, Walter Shriner, Catherine Creech.
Previous study revealed severe toxic effects of ammonia nitrogen on Ruditapes philippinarum including lysosomal instability, disturbed metabolic profiles, gill tissues with damaged structure, and variation of neurotransmitter concentrations. However, the underlying molecular mechanism was not fully understood yet.
In the present study, digital gene expression technology (DGE) was applied to Cited by: Breast cancer cells can reuse their ammonia waste to grow, research suggests.
Toxic ammonia by-products from healthy cells are generally removed from the body as urea, through the liver.
Based on the part of MngC1qR sequence that was identified in our laboratory (Sun et al., ) by a transcriptome analysis, carried out on hepatopancreatic tissues of M. nipponense. Gene-specific primers, targeting the 3′ and 5′ regions (3 L1, 3 L2 and 5 L1, 5 L2 respectively) were used to amplify the cDNA by 3′/5′-RACE 3′-full RACE core set ver.
kit and the 5′-full Author: Bing Sun, Huan Luo, Shuo Zhao, Jie-lun Yu, Xiao-ting Lv, Cao Yi, Hui Wang. PATHOPHYSIOLOGY.
Ammonia, a nitrogenous waste product of amino acid catabolism, is produced primarily by colonic flora breakdown of amino acids and urea, by enterocyte metabolism of glutamine, and by glutamine metabolism within the kidneys. 1 From ammonia to cancer and gene expression book produced from the gut is transported to the liver via the portal circulation where, in the intact liver, it is converted to the nontoxic.
None of the signatures of breast cancer gene expression reported to date 6,7,8,9,10,11,12 allow for patient-tailored therapy strategies. Cited by: Databases for oncogenomic research are biological databases dedicated to cancer data and oncogenomic research.
They can be a primary source of cancer data, offer a certain level of analysis (processed data) or even offer online data mining. This book offers a comprehensive look into the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist Cited by: Cancer Genetics is a part of Elsevier’s Oncology Journal Network.
Led by Shashikant Kulkarni, our experienced editorial board members are all active researchers in their field. The aim of Cancer Genetics is to publish high quality scientific papers on the cellular, genetic and molecular aspects of cancer, including cancer predisposition and.
Gene expression in L. vannamei in response to ammonia nitrogen and sulfide exposure The activation of caspase-3 demonstrates that cell apoptosis has entered an irreversible stage [ 44 ].
We found that, apoptosis in L. vannamei began immediately in response to severe environmental stress [ 45, 46 ].Cited by: 2. The purpose of this study was to investigate the expression of glutamine synthetase (GS) in prostate cancer (PCa) and the utility of [13N]ammonia positron emission tomography/computed tomography.
Pina A, Errea P. Differential induction of phenylalanine ammonia-lyase gene expression in response to in vitro callus unions of Prunus spp. J Plant Physiol. ; – doi: / [Google Scholar]Cited by: Cloning and characterization of a novel phenylalanine ammonia-lyase gene from Inonotus baumii.
baumii is internationally recognized as the first medicinal fungus in the field of biological cancer treatment and has become a subject of worldwide promoter from Ginkgo biloba and its regulation of gene expression in transgenic tobacco by: 2.
Relative mRNA expression of ammonia metabolizing enzymes in liver tissue of control and CPSS dogs. Significant differences between mRNA expression of the enzymes in control liver samples compared. Here we report that Myc upregulates expression of GS, the enzyme that catalyzes the formation of glutamine from glutamate and ammonia.
This Myc-induced GS expression promotes glutamine anabolism and is associated with cell proliferation, survival, and xenograft tumor growth, suggesting an important role of GS in Myc-driven by: Transcription factors play a critical role in regulating the gene expression programs that establish and maintain specific cell states in humans.
Deregulation of these gene expression programs can lead to a broad range of diseases including cancer. SOX transcription factors are a conserved group of transcriptional regulators that mediates DNA binding by a highly conserved high-mobility group Author: Li Cui, Xinyuan Zhao, Shen Hu.
Gut Microbes as Infectious Agents. It is now clear that infectious agents are important to the development of specific cancer types; cervical, anal, penile, oropharyngeal, liver, and stomach cancers, along with certain types of lymphomas, have well-established infectious etiologies [23, 42].Approximately 20 % of the total worldwide cancer burden is attributable to known infectious agents Cited by: Cancer can be described as a disease of altered gene expression.
Changes at every level of eukaryotic gene expression can be detected in some form of cancer at some point in time.
In order to understand how changes to gene expression can cause cancer, it is critical to understand how each stage of gene regulation works in normal cells.
Cancer is a category of disease characterized by uncontrolled cell growth and proliferation. For cancer to develop, genes regulating cell growth and differentiation must be altered; these mutations are then maintained through subsequent cell divisions and are thus present in all cancerous cells.
Gene expression profiling is a technique used in molecular biology to query the expression of. The fact that TNF-α expression precedes that of the ammonia transporter Rhcg suggests that it may play a role in transcriptional or posttranslational upregulation of the Rhcg gene. The fact that the timing of Rhcg expression coincides with the ammonia peak in the brain indicates that Rhcg contributes to the accumulation of ammonia in the by: 1.
Unique mitochondrial localization of arginase 1 and 2 in hepatocytes of air-breathing walking catfish, Clarias batrachus and their differential expression patterns under hyper-ammonia stress Bodhisattwa Banerjee, Debaprasad Koner, Priyanka Lal, Nirmalendu Saha.
Focusing on the areas of cancer, inflammatory and autoimmune disorders, chapters discuss three main components of the epigenome and their role in the regulation of gene expression and present a detailed method section specific to studying each component, including data analyses, troubleshooting, and feasibility in different experimental : Hardcover.
Scientists are using what is known about the regulation of gene expression in disease states, including cancer, to develop new ways to treat and prevent disease development.
Many scientists are designing drugs on the basis of the gene expression patterns within individual tumors. How can understanding the gene expression pattern in a cancer cell tell you something about that specific form of cancer.
Understanding gene expression patterns in cancer cells will identify the faulty genes, which is helpful in providing the relevant drug treatment. Understanding gene expression will help diagnose tumor cells for antigen. Researchers trying to turn off a gene that allows cancers to spread have made a surprising U-turn.
By making the gene overactive and functional in the hearts of mice, they have triggered heart. What is Cancer. ¥Cancer is a genetic disease: ÐInherited cancer ÐSporadic cancer ¥Cancer typically involves a change in gene expression/function: ÐQualitative change ÐQuantitative change ¥Any cancer causing genetic alteration typically results in loss of cell growth control.
and other androgens to survive. But some prostate cancer cells thrive despite treatments that eliminate androgens. One hypothesis is that estrogen, often considered a female hormone, may be activating genes normally controlled by an androgen in these cancer cells.
Describe one or more experiments to test this hypothesis. (See Figure to review. Some of the gene expression tests for breast cancer prognosis that have been developed are Oncotype DX, MammaPrint, PAMbased risk of recurrence score, Breast Cancer Index, and EndoPredict.
An oncologist should be able to design an individualized therapy identified by maximum benefit and minimum harm through the use of predictive : Katerina Pierouli, Thanasis Mitsis, Eleni Papakonstantinou, Dimitrios Vlachakis.
Cancer can be described as a disease of altered gene expression. Changes at every level of eukaryotic gene expression can be detected in some form of cancer at some point in time. In order to understand how changes to gene expression can cause cancer, it is critical to understand how each stage of gene regulation works in normal : OpenStaxCollege.
Gene Therapy Gone Wrong. The risks of gene therapy were realized in the case of Jesse Gelsinger, an year-old patient who received gene therapy as part of a clinical trial at the University of received gene therapy for a condition called ornithine transcarbamylase (OTC) deficiency, which leads to ammonia accumulation in the blood due to deficient ammonia processing.
The hypoxia-inducible factor-1α (HIF-1α) is an evolutionarily conserved transcription factor with prominent roles in the hypoxic response, cell survival, angiogenesis and cancer. HIF-1α functions as a sensor of molecular oxygen: in the presence of oxygen, it is degraded by the proteasome, whereas in reduced oxygen tensions, it heterodimerizes with the constitutively expressed HIF-1b subunit Author: Vasilia Tamamouna, Chrysoula Pitsouli.
The detoxification of ammonia occurs mainly through conversion of ammonia to urea in the liver via the urea cycle and glutamine synthesis. Congenital portosystemic shunts (CPSS) in dogs cause hyperammonemia eventually leading to hepatic encephalopathy.
In this study, the gene expression of urea cycle enzymes (carbamoylphosphate synthetase (CPS1), ornithine carbamoyltransferase (OTC Cited by: 9. The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer.
Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials. are upregulated in many tumor types and play key roles in gene expression. Recently, it has become apparent that the pathogenesis of cancer is closely connected with aberrantly regulated apoptotic cell death and the resulting deregulation of cell proliferation.
The loss of equilibrium between cell proliferation and cell death in a tissue may play a crucial role in tumor formation.
In fact, the initiation of uncontrolled apoptosis in a tissue may serve as the trigger Author: Chanda Siddoo-Atwal.
The Laboratory of Pathology (LP) at the National Cancer Institute (NCI) is an integral component of the research and clinical community at the National Institutes of Health (NIH).
Our goal is to be a globally recognized center of excellence in disease research, clinical diagnostics, and pathology education. The mission of the Laboratory of. Asparagine synthetase (or aspartate-ammonia ligase) is a chiefly cytoplasmic enzyme that generates asparagine from aspartate.
This amidation reaction is similar to that promoted by glutamine enzyme is ubiquitous in its distribution in mammalian organs, but basal expression is relatively low in tissues other than the exocrine : Because harmful BRCA1 and BRCA2 gene mutations are relatively rare in the general population, most experts agree that mutation testing of individuals who do not have cancer should be performed only when the person’s individual or family history suggests the possible presence of a harmful mutation in BRCA1 or BRCA2.
Cancer: Disease of Altered Gene Expression. Cancer can be described as a disease of altered gene expression. There are many proteins that are turned on or off (gene activation or gene silencing) that dramatically alter the overall activity of the cell.
A gene that is not normally expressed in that cell can be switched on and expressed at high.Some of the genes affected by cytosine methylation in melanoma formation.
INK4A. INK4A, also known as p16, is a tumor suppressor gene and is found to have hypermethylated promoter regions in 20% of melanoma cells and is involved in 87% of gene alterations in melanoma cases (Gonzalgo et al., ). This means that 20% of the time there is an epigenetic change in the INK4A gene, and.Zinc transporter ZIP6 is a protein that in humans is encoded by the SLC39A6 gene.
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and s: SLC39A6, LIV-1, ZIP6, solute carrier family 39 .